thyroid peroxidase การใช้

• The risk is higher in those with antibodies against thyroid peroxidase.
• Antibodies against thyroid peroxidase can be found on testing.
• In diagnostic immunohistochemistry, the expression of thyroid peroxidase ( TPO ) is lost in papillary thyroid carcinoma.
• This makes it more reactive, and the iodine is attached to the active tyrosine units in thyroglobulin by the enzyme thyroid peroxidase.
• Even maternal thyroid peroxidase antibodies were shown to be associated with impaired intellectual development in the offspring of mothers with normal thyroid function.
• Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of patients may have none of these antibodies present.
• Diagnosis is usually made by detecting elevated levels of anti-thyroid peroxidase antibodies ( TPOAb ) in the serum, but seronegative ( without circulating autoantibodies ) thyroiditis is also possible.
• For example, the closely related thyroid peroxidase catalyzes a specific oxidation reaction in the biosynthesis of a hormone, while other heme peroxidases fulfill roles in immune defense and redox signalling.
• The presence of antibodies against thyroid peroxidase ( TPO ) makes it more likely that thyroid nodules are caused by autoimmune thyroiditis, but if there is any doubt a needle biopsy may be required.
• Measuring specific antibodies, such as anti-TSH-receptor antibodies in Graves'disease, or anti-thyroid peroxidase in Hashimoto's thyroiditis  a common cause of hypothyroidism  may also contribute to the diagnosis.
• Investigations into reactive oxygen species ( H 2 O 2 utilized by thyroid peroxidase ( TPO ) for the biosynthesis of thyroid hormones, supported by the discovery of congenital hypothyroidism resultant from an inactivating mutation in the " DUOX2 " gene.
• American guidelines recommend that treatment be considered if the TSH is elevated but below 10 mIU / l in people with symptoms of hypothyroidism, detectable antibodies against thyroid peroxidase, a history of heart disease or are at an increased risk for heart disease.
• American guidelines recommend that treatment should be considered if the TSH is elevated but below 10 mIU / l in people with symptoms of hypothyroidism, detectable antibodies against thyroid peroxidase, a history of heart disease or are at an increased risk for heart disease.
• Thyroid antibodies  both anti-thyroid peroxidase antibodies ( anti-TPO, anti-thyroid microsomal antibodies, anti-M ) and antithyroglobulin antibodies ( anti-Tg )  in the disease are elevated but their levels do not correlate with the severity.
• On the basis of sequence similarity, a number of animal heme peroxidases can be categorized as members of a superfamily : myeloperoxidase ( MPO ); eosinophil peroxidase ( EPO ); lactoperoxidase ( LPO ); thyroid peroxidase ( TPO ); prostaglandin H synthase ( PGHS ); and peroxidasin.
• As such, it is recommended that treatment should be taken into account for patients with initial TSH levels > 10 mIU / L, people with elevated thyroid peroxidase antibody titers, people with symptoms of hypothyroidism and TSH levels between 5 10 mIU / L, and women who are pregnant or want to become pregnant.